Now a day I have faced this issue and I was quite frustrated for a long time how to short out this issue. Normally we get below error log in event viewer.
Faulting application name: devenv.exe, version: 16.8.30709.132, time stamp: 0x5fa9c41f
Faulting module name: KERNELBASE.dll, version: 10.0.14393.3986, time stamp: 0x5f77edfa
Exception code: 0xe0434352
Fault offset: 0x000dc562
Faulting process id: 0x27a0
Faulting application start time: 0x01d780453a839eec
Faulting application path: C:\Program Files (x86)\Microsoft Visual Studio\2019\Professional\Common7\IDE\devenv.exe
Faulting module path: C:\Windows\System32\KERNELBASE.dll
Report Id: 84d1dcc3-7d3d-4397-bfd6-40945ddb2029
Faulting package full name:
Faulting package-relative application ID:
When ever I tried to open BizTalk orchestration. My visual studio crashed. I have search a lot and installed cumulative updated also but no luck.
Finally I had to downgraded Visual studio 2019 latest version to Version 16.4.15. And this work for me.
Hopefully It will work for you also.
Visual Studio Release Version: